Research

IMGC Research Projects

: Cow, Mouse, and Human Milk and Lactation Genome Browsers
This highly valuable data resource includes milk protein genes, development stage-specific mammary genes, milk trait QTLs, milk trait candidate genes, statistically significant clusters of milk and mammary genes, and mammalian orthologs (human, mouse, rat, dog, opossum, platypus) of the bovine milk and mammary genes.

: MamExp (MammoXpressionist): an interactive gene expression browser interface for collaborative comparative lactation genomics.
The increasing use of high throughput gene expression microarray analysis in lactation research is rapidly producing a large compendium of results on the expression of genes in the mammary tissue of an accruing number of species (bovine, mouse, human, seal, wallaby, monotremes…). Comparison of data from different species provides new opportunities to better understand the function of genes in the mammary gland and may ultimately lead to increased potential for applications to enhanced lactation in dairy cattle. The storage of mammary gene expression data, usually provided in a data exchange portal, does not allow the direct retrieval of gene expression lists or the comparison of lactation results from independent experiments or species. We are developing on-line facilities for the interrogation of gene expression data series and the reciprocal interspecies mapping of genes to facilitate the retrieval and visualization of gene expression data and the comparison of experimental results. Here, we propose to expand the database to include new data made available through the IMGC portal or otherwise made available in gene expression depository and enhance the functionality by customizing query interfaces and simplifying data upload. These developments will result in the provision of on-line data storage and retrieval interfaces for the interrogation and visualization of gene expression data related to mammary physiology and, will enable a more interactive comparative approach for the collaborative curation and analysis of microarray data.

Lactation genes, proteins, pathways, and networks

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: Milk's role in directing the infant microbiome
This IMGC portal project disseminates B. infantis genes active on milk substrates encountered within the infant gut.

: An Integrated Lactome Dataset
The collective set of genes that contribute to the production of milk may be referred to as the “lactome”. This dataset is derived from analysis of multiple inbred mouse strains. The data includes links to electronic databases that provide detailed annotation for each element.

Microarray data sets in lactation science

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