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Temporal Variance in the Human Milk Glycoproteome
J.W. Froehlich, E.D. Dodds, R.R. Seipert, E.L. McJimpsey, C.B. Lebrilla – University of California, Davis
While some of the most abundant proteins in human milk are
glycosylated, the carbohydrate composition, glycosylation sites, and
glycan heterogeneity among milk glycoproteins remain poorly
characterized. In this study, contemporary proteomic and
glycoproteomic techniques are applied to human milk sampled at
different timepoints, with an emphasis on analyzing the glycosylated
proteins and identifying their glycans. Semi-quantitative
gel-based methods simultaneously quantify several abundant proteins,
and demonstrate the variance in level of glycosylation and raw amount
of specific proteins present in human milk over lactation time for five
individuals.
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