Topic: antibodies

Antibody Type, Specificity, and Source Influence Their Survival in the Infant Gut

Antibody Type, Specificity, and Source Influence Their Survival in the Infant Gut

Maternal antibodies play an important role in protecting newborns from harmful pathogens. Antibodies known as immunoglobulins (Igs) are transferred from the mother’s placenta into the fetus, where they protect the infant while the infant’s immune system is still developing, Human milk also contains many different Igs, such as IgA, IgM, IgG, and secretory forms of IgA and IgM. Consuming human milk provides additional immune protection to infants and has been shown to reduce the risk of infectious diseases. Read More...

From Mother’s Gut to Milk

From Mother's Gut to Milk

In a world filled with harmful bacteria, viruses, and parasites, it seems quite paradoxical that a human infant would be born with an immature and inefficient immune system. That is, of course, until you realize the infant benefits from mom’s immune system hard at work in mucosal surfaces. The process of transferring immunity, also known as passive immunity, begins during pregnancy with the transfer of Immunglobulin G (IgG) cells from maternal to fetal circulation through the placenta. At birth, the mammary gland takes over, providing numerous types of immunogloblulins (antibodies) and other immune factors. Read More...

Chimeric Milk Antibodies Bind More Pathogens

Chimeric Milk Antibodies Bind More Pathogens

If antibodies were superheroes, then human milk secretory immunoglobulin A (sIgA) would be “The Avengers”, taking on the pathogens no single superhero could stand. Milk sIgA is able to protect infants against a multitude of respiratory and gastrointestinal pathogens, including E. coli, salmonella, and pneumonia. But perhaps its greatest known power comes from its unique molecular structure—two IgA molecules held together by a joining chain (J) and a secretory component (s)—allowing sIgA to resist degradation by gastrointestinal enzymes. This makes it one of the few immune factors at the front lines able to bind bacteria and viruses before they attach to the infant’s gastrointestinal tract. Read More...

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