KEYNOTE: Glycomic and glycoproteomic variations of human milk

Carlito Lebrilla, Dept. of Chemistry, University of California, Davis, USA

Glycans play key roles in diseases and in maintaining health. Despite their importance, our abilities to measure and determine precise structures have been limited because of the large structural heterogeneity and the complicated structures. Our research has focused on developing advanced separation methods, accurate and structurally informative mass spectrometry techniques and automated informatics tools that now make rapid throughput profiling of glycans possible. These methods are employed to determine the role of glycans in nutrition allowing us to observe and characterize the glycan characterization during lactation. Glycan profiling of human milk oligosaccharides and glycoconjugates including glycoproteins and glycolipids are further helping us understand how these compounds establish the gut microbiome.

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