subject: antibody

Infants Take Active Role in Passive Immunity

Infants Take Active Role in Passive Immunity

The transfer of immune components from a nursing mother to her offspring is called passive immunity. Calling this system passive, however, wrongly implies that antibodies, macrophages, and other anti-microbial factors in milk are simply along for the ride with the nutritional factors that transfer from the maternal blood stream. Numerous studies have demonstrated that maternal factors such as nutrition, stress, and illness influence the concentration of immunological constituents in milk (1-3). And now, a growing body of research, including a new study by Breakey et al. (4), indicates that passive immunity may be actively influenced by the health status of the breastfeeding infant (5-7). Can a sick infant actually increase the quantity of particular immune factors in their mother’s milk to help fight off infection? Read More...

Breast Milk Antibody Promotes a Healthy Gut into Adulthood

Breast Milk Antibody Promotes a Healthy Gut into Adulthood

Many pediatrics studies have shown that inflammatory bowel disease is more common in infants who are not breast fed than in those who are. But explaining why this is the case has been hard. Recently, Charlotte Kaetzel and her colleagues at the University of Kentucky, Lexington, went further in demonstrating a mechanistic link than any group has done before. They report1 that an antibody (SIgA) transmitted in breast milk from mom to babe alters the expression of genes in infants’ gut epithelial cells. Not only are these genes associated with the development of irritable bowel syndrome, but the changes appear to last into adulthood. Read More...

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