subject: insulin signaling

Insulin Control = More Mammary Tissue, More Milk, Bigger Babies

Insulin Control = More Mammary Tissue, More Milk, Bigger Babies

We know insulin as a regulator of blood sugar, but it also influences cell growth and differentiation. This is especially relevant to mammary tissue during pregnancy and lactation. A role for insulin in lactation has been accepted for some time, but some questions have remained about its role during pregnancy—when the mammary gland is developing—and the relative roles of insulin and insulin-like growth factors. Clarifying the role of insulin in lactation was the aim of the study by Neville and colleagues. They used a mouse model system, and in an elegant approach, bred a mouse line in which the receptor for insulin was selectively deleted in the cells that produce milk. Read More...

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